Relationship of Agitation and Aggression in Alzheimers disease (AD) and MCI

 
   Lead Investigator:    Paula Trzepacz
   Institution      :    Eli Lilly and Company
   E-Mail           :    PTT@lilly.com
   Proposal ID      :    133



   Proposal Description:
   Abstract: A limited literature using various neuroimaging methods and post-mortem data suggests that fronto-limbic neuropathology of gray and/or white matter is associated with greater agitation and aggression in AD. Behavioral problems are especially difficult to manage, lead to caregiver distress and hasten institutionalization.  Specific Aims: Analyze data from the NPI-Q items related to agitation and aggression symptom severity in MCI and AD groups and determine which MRI ROI volumes and/or cortical thickness measures s are most associated  with greater behavioral symptom severity, after preselecting a subset of ROIs [Freesurfer?]. Compare functional neuroimaging relationships for fMRI for relationship to behaviors.